The early MVP favourite is unable to play on Sunday night.
The 27-year-old former MVP finalist is averaging a league-high 40.1 points to go along with 7.8 rebounds and 7.7 assists through eight games this season.
Doncic scored a season-high 53 points and played 38 minutes in the Lakers’ win over the Portland Trail Blazers on Friday.
Wilt Chamberlain is the only player in NBA history to average over 40 points in a season, doing so in both 1961-62 and ’62-63.
The Lakers are tied for first in the Western Conference with an 8-2 record.
However, their secondary scoring options in Austin Reaves and Walker Kessler will need to step up in Doncic’s absence to keep rolling against the 6-2 Pistons.