Rams vs. Cardinals odds: Opening lines for Week 10 matchup

Posted by Admin November 9, 2026 NFL

FanDuel has the Los Angeles Rams as 7.5 favorites over the Arizona Cardinals entering Week 10. Considering the Cardinals are the home team, that is a fairly massive spread in favor of L.A. Throw in AZ beat the Rams earlier this season, though the Rams won in Week 9, their offense struggled once again throughout the game. Week 10 is not a lock for the Rams.

L.A.’s defense has been the star of the show for the Rams in 2026 more so than the offense. Throw in the possibility that Puka Nacua could miss week 10, and that 7.5 point spread seems even less likely for the Rams to cover.

It should be interesting and worth monitoring to see if Gardnew Minshew get another start for Arizona as they could want to see rookie Carson Beck at some point, but that may not be against Myles Garrett and the Rams.

Garrett had three sacks in Week 9, does he get another in Week 10? Will Aaron Donald get his first sack of the year in Arizona? Will Matthew Stafford throw more than one touchdown pass? Will Blake Corum out carry Kyren Williams? Does Trent McDuffie make his return for the Rams?

There’s plenty of variables to consider, so pay attention as that 7.5 line could move between now and Sunday.

Will this particular matchup be another low scoring affair like their earlier season game? Neither the Rams or Cardinals broke 20 points in their first contest, does that change the second time around?

The Cardinals just lost to the Seattle Seahawks, and they’ll likely need to win against the Rams to keep their season alive from a playoff perspective. For the Rams, they are 5-4, but their margin for error is likely too small to drop Week 10’s game and still expect to make a real postseason push.

There’s a lot on the line at this point in the season, and you can check out FanDuel to bet on the Cardinals or Rams and more NFL games. Bet responsibly.