The 23-year-old landed awkwardly and was reportedly seen stretching out his ankle on the sideline before exiting to the locker room. However, Banchero returned before ultimately exiting for good at the end of the third quarter.
The Magic lost 115-93 and fell to 0-2 on the season.
Banchero scored 14 points and added six rebounds and five assists in 26 minutes.
A first-overall pick in the 2022 NBA Draft, Banchero missed nearly half of 2024-25 with a torn oblique muscle but rebounded to play 72 games last season.
However, the Magic’s other star forward, Franz Wagner, struggled with calf and ankle injuries last season and played just 34 games.
Orlando added Desmond Bane to its promising young core last off-season, but has still not won a playoff series since 2010.