Bills wide receiver DJ Moore was injured while diving for a Josh Allen pass in the end zone.
Moore is in the X-ray room for further evaluation after coming down hard on his left shoulder and then having Lions cornerback Rock Ya-Sin land on top of him.
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The Bills list Moore as questionable to return with a shoulder injury and a possible stinger, according to Prime sideline reporter Kaylee Hartung.
The Bills scored on the next play, as Josh Allen connected with tight end Dalton Kincaid for a 16-yard touchdown. Tyler Bass missed the extra point wide left. The Bills lead 27-7 with 2:52 remaining in the second quarter.