The Detroit Lions hit the road for the first time in the 2026 season, traveling to Highmark Stadium to play the Buffalo Bills in their home opener at their brand-new stadium.

“Obviously, really good opponent. I know Joe Brady very well; that’s a heck of a start there,” Dan Campbell said during Monday’s press conference. “Can’t say enough about this quarterback; he’s a catalyst for them. This is a good O-line, they got weapons, it’s a good back. This defensive line is their catalyst over there: Ed Oliver and (Greg) Rousseau, man, really good player, length, explosive. They got Chubb on the other end. Big boy in the middle, it’s an active defense and it’s a big win for them yesterday. We got our hands full. They’re aggressive on special teams. It’s opening night out at their place Thursday night; it’ll be electric. You know, it’s going to be a great atmosphere. We’ll be looking forward to that. Excellent opponent. This will be a big time game here early in the year.”

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Here’s a look at our Pride of Detroit staff picks for the Lions in Week 2:

For the rest of the POD staff’s NFL predictions, check out our Week 2 predictions: Moneyline, spread, and over/under, which will be coming on Sunday morning.

Now you can use your voice! Share what you think the game score will be in the comment section at the bottom of the page and vote in the poll directly below. Can the Lions spoil the Bills’ opening game in their new stadium, or will the Bills showcase why they’re a favorite in the AFC?