The New England Patriots are the reigning AFC East champions, but you wouldn’t know looking at them right now. At 1-2 and coming off a 35-6 blowout loss to the Jacksonville Jaguars, they are struggling to recapture last year’s magic.
The Buffalo Bills have none of those issues. The 2025 division runner-ups are 3-0 and despite some hiccups in their Week 3 win over the Los Angeles Chargers are looking like one of the best teams in the NFL right now.
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Unsurprisingly, the Bills are therefore heavy favorites over the Patriots in Week 4, as as a look at the odds presented by FanDuel Sportsbook shows.
Moneyline: Patriots +265 | Bills -330
The Patriots visiting Buffalo as underdogs is nothing new. Last year, for instance, they were seen as 9-point ‘dogs heading into a Week 5 matchup with the then-undefeated Bills — a game they eventually ended up winning 23-20 in upset fashion.
Of course, no two teams and circumstances are alike. For the Patriots to pull off a similar upset this time around, significant improvement is needed.
Kickoff between the two AFC East rivals in Orchard Park, NY, is scheduled for 1 p.m. ET on Sunday, Oct. 4.
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