Colts tight end Tyler Warren left practice early after going down on a route in 11-on-11 drills.
James Boyd of TheAthletic.com reports that Warren appeared to injure a groin.
Warren left with an athletic trainer and returned to the sideline without a helmet.
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A first-round pick in 2025, Warren caught 76 passes for 817 yards with four touchdowns in 17 games as a rookie.
Running back DJ Giddens, who has missed recent practice time with a hamstring injury, went through individual drills Wednesday. He left with an athletic trainer, indicating his hamstring.